Manufacturer
Aurobindo pharma
Contents
Captopril 12.5mg
Indication
Hypertension, Post-myocardial infarction, Diabetic nephropathy, Congestive heart failure.
Instruction
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Drug interaction
Increases lithium concentration and toxicity. Increased risk of leucopenia with procainamide and immunosuppresants. Decreased renal clearance with probenecid. Enhances hypotensive effect of TCA and antipsychotics. Decreased antihypertensive effects with sympathomimetic agents. Increased hypotensive effect with adrenergic blocking agents and NSAIDs (e.g. indomethacin, ibuprofen). Potentiates blood glucose-lowering effects of insulin and oral antidiabetics (e.g. sulphonylureas). May result in volume depletion and risk of hypotension with thiazide or loop diuretics (except furosemide and hydrochlorothiazide). May increase serum K with K-sparing diuretics (e.g. amiloride, spironolactone, triamterene), K-containing salt substitutes or supplements. Increased risk of low renal function due to serum K increase with NSAIDs. Increased risk of angioedema with neprilysin inhibitor and mammalian target of rapamycin inhibitor (e.g. temsirolimus, everolimus). Potentially Fatal: Increased risk of hypotension, hyperkalaemia and impaired renal function with aliskiren. Increased risk of angioedema with neprilysin inhibitors (e.g. sacubitril). May cause anaphylactoid reactions with dextran sulfate in LDL apheresis.
Malaysia
