Manufacturer
PHARMANIAGA MANUFACTURING BERHAD
Contents
Alexitol Na (equiv to Al (OH)3 200 mg) 333 mg, Mg (OH)2 152 mg, simethicone 25 mg
Indication
The relief of stomach discomfort such as indigestion, heartburn due to gastric hyperacidity (excessive acid) and peptic ulcer (an ulcer of the stomach, duodenum or lower end of esophagus).
Instruction
Adult (tablet must be chewed) Gastric : Chew 1 to 2 tablets : 1/2 to one hour after each meal. Heartburn : Chew 1 to 2 tablets, before breakfast and half hour after each meal. Indigestion : Chew 1 to 2 tablets. Peptic ulcer : Chew 2 to 4 tablets. Do not take more than 8 tablets in a 24 hour period or use the maximum dosage for more than 2 weeks, except under the supervision of a physician.
Drug interaction
Antacids interact with many other medicines both by alterations in gastric acidity and emptying, and by formation of complexes that are not absorbed. Interactions can be minimized by giving the antacid and any other medications 2 to 3 hours apart. ACE Inhibitors: antacids reduce absorption of fosinopril. Analgesics: excretion of aspirin increased in alkaline urine; antacids reduce absorption of diflunisal. Anti-arrhythmics: excretion of quinidine reduced in alkaline urine (may occasionally increase plasma concentrations). Antibacterials: antacids reduce absorption of azithromycin, cefpodoxime, ciprofloxacin, isoniazid, nitrofurantoin, norfloxacin, ofloxacin, pivampicillin, rifampicin, and most tetracyclines. Antiepileptics: antacids reduce absorption of gabapentin and phenytoin. Antifungals: antacids reduce absorption of itraconazole and ketoconazole. Antiplatelet Drugs: dipyridamole patient information leaflet advises avoidance of antacids. Antimalarials: antacids reduce absorption of chloroquine and hydroxychloroquine. Antipsychotics: antacids reduce absorption of phenothiazines. Bisphosphonates: antacids reduce absorption. Iron: magnesium trisilicate reduces absorption of oral iron. Lithium: sodium bicarbonate increases excretion (reduced plasma-lithium concentration). Mycophenolate Mofetil: antacids reduce absorption of mycophenolate mofetil. Penicillamine: antacids other medicines, including medicines obtained without a prescription. This includes herbal medicines.
Malaysia
