Manufacturer
PHARMANIAGA LIFESCIENCE SDN. BHD.
Contents
Flumazenil
Indication
Reversal of benzodiazepine-induced sedation, Benzodiazepine overdose.
Instruction
Adult : IV Reversal of benzodiazepine-induced sedation Anaesth: Initial: 200 mcg over 15 sec; 2nd dose of 100 mcg can be given if desired degree of consciousness is not obtained w/in 60 sec. May be repeated at 60-sec intervals if necessary. Usual: 300-600 mcg. Max: 1,000 mcg. Intensive care: Initial: 300 mcg over 15 sec; repeat dose of 100 mcg may be administered if desired degree of consciousness is not obtained w/in 60 sec. May be repeated at 60-sec intervals if necessary. Max: 2,000 mcg. Benzodiazepine overdose Initial: 200 mcg over 30 sec; additional dose of 300 mcg may be given after 30 sec, followed by 500 mcg at 60-sec intervals if required. Max: 3,000 mcg or 5,000 mcg. Alternatively, infusion may be given at 100-500 mcg/hr, adjusted according to response.
Drug interaction
Antagonises central effects of benzodiazepines and non-benzodiazepine agonists (e.g. zopiclone, triazolopyridazine) by competitive interaction at the receptor. Potentially Fatal: Toxic effects of other psychotropic products esp TCAs taken concurrently may increase w/ the subsidence of benzodiazepine effect.
Malaysia
