Manufacturer
PHARMANIAGA MANUFACTURING BERHAD
Contents
Ceftriaxone
Indication
Acute otitis media, Uncomplicated gonorrhoea, Syphilis, Susceptible infections, Lyme disease, Prophylaxis of surgical infections.
Instruction
Adult: IV/IM Susceptible infections 1-2 g daily, increased to 4 g daily in severe infections, given once or in 2 divided doses. Dose >2 g is given via IV inj or infusion. Syphilis 0.5-1 g once daily, increased to 2 g once daily for neurosyphilis for 10-14 days. Lyme disease 2 g once daily for 14-21 days. Prophylaxis of surgical infections 1-2 g as a single dose given 0.5-2 hours before surgery. All doses are given via slow IV inj over 5 minutes, or infused over at least 30 minutes, or deep IM inj. IM Uncomplicated gonorrhoea 250-500 mg as a single dose. Acute otitis media 1-2 g as a single dose.
Drug interaction
May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate.Potentially Fatal: Admin with Ca-containing IV solution may cause precipitation of a crystalline material in the lungs and kidneys.
Malaysia
