Manufacturer
Troikaa Pharmaceuticals Ltd
Contents
Propofol
Indication
Sedation, Induction and maintenance of general anaesthesia.
Instruction
Adult: IV Induction and maintenance of general anaesthesia As 1% emulsion given via inj or infusion or as 2% emulsion given via infusion: Induction: 40 mg every 10 seconds, titrated until clinical response is achieved. Usual dose: 1.5-2.5 mg/kg. Maintenance: 4-12 mg/kg/hr continuous infusion. Alternatively, 25-50 mg intermittent bolus inj of 1% emulsion. Target-controlled infusion (TCI) delivery system may also be used based on target blood concentrations, refer to detailed product guideline. Sedation In surgical and diagnostic procedures: Initially, 6-9 mg/kg/hr infused over 3-5 minutes. Alternatively, 0.5-1 mg/kg via slow injection over 1-5 minutes. Maintenance: 1.5-4.5 mg/kg/hr via infusion. Additional 10-20 mg incremental bolus inj as 1% emulsion may be given if rapid increase in the depth of sedation is required. As 1% or 2% emulsion: In intensive care setting: Induction and maintenance: 0.3-4 mg/kg/hr via infusion over 5 minutes. Rate of administration may be individualised and titrated based on desired depth of sedation.
Drug interaction
Additive sedative/anaesthetic and cardiorespiratory depressant effect with other CNS depressants. Profound hypotension with rifampicin. Valproate may increase serum levels of propofol.
Malaysia
