Manufacturer
NOVARTIS PHARMA STEIN AG
Contents
Everolimus
Indication
In combination w/ ciclosporin for microemulsion & corticosteroids for the prophylaxis of organ rejection in adult patients at low to moderate immunological risk receiving an allogeneic renal or cardiac transplant. In combination w/ tacrolimus & corticosteroids for the prophylaxis of organ rejection in patients receiving hepatic transplant.
Instruction
May be taken with or without food: Take consistently either always w/ or always w/o meals. Avoid grapefruit products.
Drug interaction
CYP3A4 & CYP2D6 substrates w/ narrow therapeutic index. Rifampicin, rifabutin or ketoconazole, itraconazole, voriconazole, clarithromycin, telithromycin or ritonavir, midazolam, St. John's wort, erythromycin, fluconazole, phenytoin, carbamazepine, phenobarb, Ca-channel blockers, PIs, anti-HIV drugs. Grapefruit & grapefruit juice; live vaccines.
Malaysia
