Manufacturer
Merck Sharp & Dohme
Contents
24 active tab each containing Nomegestrol acetate 2.5 mg, estradiol (as hemihydrate) 1.5 mg & 4 placebo tab
Indication
Oral contraceptive
Instruction
May be taken with or without food.
Drug interaction
Breakthrough bleeding & contraceptive failure with enzyme-inducing medicinal products. Increased clearance, reduced plasma conc & decreased effectiveness w/ phenytoin, phenobarb, primidone, bosentan, carbamazepine, rifampicin, St. John's wort, oxcarbazepine, topiramate, felbamate, griseofulvin, ritonavir, nelfinavir, nevirapine & efavirenz. Increased or decreased plasma conc w/ nelfinavir, nevirapine, boceprevir, telaprevir. Increased serum conc w/ strong (eg, ketoconazole, itraconazole, clarithromycin) or moderate (eg, fluconazole, diltiazem, erythromycin) CYP3A4 inhibitors. Increased plasma & tissue conc of ciclosporin. Decreased plasma & tissue conc of lamotrigine.
Malaysia
