Manufacturer
Novartis
Contents
Per mL Brinzolamide 10 mg, brimonidine tartrate 2 mg
Indication
Decrease of elevated IOP in adults w/ open-angle glaucoma or ocular HTN for whom monotherapy provides insufficient IOP reduction.
Instruction
Adult including elderly 1 drop in affected eye bd.
Drug interaction
Blunted ocular hypotensive response by TCAs. Additive or potentiated effect w/ CNS depressants. Affected metabolism & uptake of circulating amines eg, chlorpromazine, methylphenidate, reserpine, serotonin–norepinephrine reuptake inhibitors. Reduced pulse & BP w/ α-adrenergic agonists. Concomitant use w/ antihypertensives &/or cardiac glycosides; isoprenaline, prazosin. Additive systemic effects w/ oral carbonic anhydrase inhibitors. Inhibited metabolism w/ CYP3A4 inhibitors.
Malaysia
