Jadelle Implants

Manufacturer
Bayer Oy
 
Contents
75 mg of the progestin levonorgestrel.
 
Indication
Prevention of pregnancy and are a long-term (up to 5 years) reversible method of contraception.
 
Instruction
Insertion of the two implants should be performed during the first 7 days following the onset of menses by a health-care professional familiar with the levonorgestrel implant insertion technique. It is strongly recommended that all health-care providers receive instruction in the proper insertion and removal procedures. Insertion is subdermal in the midportion of the inner surface of the upper arm about 8 to 10 cm above the medial epicondyle. The two implants should be placed in a ''V'' shape about 30 degrees apart. Proper insertion will facilitate removal
 
Drug interaction
Jadelle implants are not recommended for women who require chronic use of phenytoin, phenobarbital, carbamazepine or oxcarbazepine because Jadelle is likely to be less effective for these women. Although the large clinical trials of NORPLANT® and of Jadelle implants excluded women with epilepsy, there are published studies showing decreased levonorgestrel concentrations in women taking these antiepileptic drugs along with levonorgestrel-containing contraceptives. These drugs may increase the metabolism of levonorgestrel through induction of microsomal liver enzymes. For women receiving long-term therapy with hepatic enzyme inducers, a different method of contraception should be considered. Women on short-term therapy with hepatic enzyme inducers should consider using a back-up method of contraception (such as condoms or spermicides) for the duration of therapy.
Rifampicin is known to decrease the effectiveness of combination oral contraceptives; its effect on levonorgestrel concentrations has not been established. Data from clinical trials of NORPLANT implants, however, indicate low serum concentrations and subsequent pregnancy in one woman using rifampicin.
Herbal products containing St. John's Wort (hypericum perforatum) may induce hepatic enzymes (cytochrome P450) and may reduce the effectiveness of contraceptive steroids.