Manufacturer
GlaxoSmithKline Manufacturing S.p.A
Contents
Mivacurium Cl
Indication
Adjunct to general anesth to relax skeletal muscles, facilitate tracheal intubation & mechanical ventilation.
Instruction
IV inj Tracheal intubation Adult 0.2 mg/kg over 30 sec or 0.25 mg/kg as divided dose (0.15 mg/kg followed by 0.1 mg/kg after 30 sec). Bolus dose: 0.07-0.25 mg/kg. Childn 7 mth-12 yr & infant 0.2 mg/kg. Bolus dose: 0.1-0.2 mg/kg over 5-15 sec. Maintenance: 0.1 mg/kg. Infant 2-6 mth Bolus dose: 0.1-0.15 mg/kg over 5-15 sec. Maintenance: 0.1 mg/kg. IV infusion Adult 8-10 mcg/kg/min. Dose adjustment may be given in increments approx 1 mcg/kg/min. Childn 2-12 yr Approx 13-14 mcg/kg/min under halothane or narcotic anaesth, 7-23 mth Approx 11 mcg/kg/min (range: 5-31 mcg/kg/min). Infant 2-6 mth Approx 11 mcg/kg/min (range: 4-24 mcg/kg/min).
Drug interaction
Potentiated by inhalational anaesth eg, enflurane, isoflurane, sevoflurane & halothane. Increased magnitude &/or duration w/ aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin, clindamycin; propranolol, Ca-channel blockers, lidocaine, procainamide, quinidine; furosemide & possibly thiazides, mannitol, acetazolamide; Mg & lithium salts; ketamine; trimetaphan, hexamethonium. Prolonged neuromuscular blocking action w/ drugs known to reduce plasma cholinesterase activity eg, anti-mitotic drugs, MAOIs, ecothiopate iodide, pancuronium, organophosphates, anticholinesterases, certain hormones, bambuterol & SSRI. May aggravate or unmask latent myasthenia gravis w/ β-blockers, anti-arrhythmics, antirheumatics, trimetaphan, chlorpromazine, steroids, phenytoin & lithium. Prolonged & complex block w/ suxamethonium Cl.
Malaysia
