Manufacturer
GLAXO WELLCOME OPERATIONS UK LTD
Contents
Zidovudine
Indication
Short-term management of serious manifestations of HIV infection in patients w/ AIDS who are unable to take oral formulations.
Instruction
Infants unable to receive oral dosing should be given RETROVIR infusion intravenously at 1.5 mg/kg bodyweight infused over 30 minutes every 6 hours.IV infusion: RETROVIR therapy should be initiated by a physician experienced in the management of HIV infection.The required dose of RETROVIR I.V. for Infusion must be administered by slow intravenous infusion of the diluted product over a one-hour period.
Drug interaction
Decreased metabolism rate by atovaquone. Reduced absorption by clarithromycin. Increased Cmax w/ lamivudine. Lowered phenytoin blood levels. Increased mean t½ & AUC by probenecid. Decreased AUC w/ rifampicin. Inhibited intracellular phosphorylation of stavudine. Altered metabolism by aspirin, codeine, morphine, methadone, indomethacin, ketoprofen, naproxen, oxazepam, lorazepam, cimetidine, clofibrate, dapsone & isoprinosine. Increased risk of adverse reactions w/ potentially nephrotoxic or myelosuppressive drugs.
Malaysia
