Manufacturer
GLAXO OPERATIONS UK LTD
Contents
Lapatinib ditosylate
Indication
HER2 overexpressing advanced or metastatic breast cancer and HER2 overexpressing hormone receptor positive metastatic breast cancer.
Instruction
Should be taken on an empty stomach. Take at least 1 hr before or 1 hr after a meal. Do not eat/drink grapefruit products.
Drug interaction
May increase the serum levels of CYP3A4, CYP2C8 and P-glycoprotein substrates. Increased exposure w/ CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, atazanavir, ritonavir). CYP3A4 inducers (e.g. carbamazepine, rifampicin) may reduce exposure to lapatinib. Increased risk of QT prolongation w/ drugs known to prolong QT intervals (e.g. antiarrythmic agents, cumulative high-dose anthracycline therapy). May increase serum levels of digoxin.
Malaysia
