Manufacturer
Pfizer Manufacturing Deutschland GmbH.
Contents
Palbociclib
Indication
In combination w/ letrozole for the treatment of postmenopausal women w/ estrogen receptor (ER) +ve, human epidermal growth factor 2 (HER2) -ve advanced breast cancer as initial endocrine-based therapy for metastatic disease.
Instruction
Should be taken with food: Take at the same time each day. Swallowwhole, do not chew/crush/open.
Drug interaction
Increased plasma exposure w/ strong CYP3A4 inhibitors (eg, clarithromycin, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, saquinavir, telaprevir, telithromycin, verapamil & voriconazole; grapefruit/grapefruit juice). Decreased plasma exposure w/ strong (eg, phenytoin, rifampin, carbamazepine & St. John's wort) & moderate (eg, bosentan, efavirenz, etravirine, modafinil & nafcillin) CYP3A4 inducers. Increased exposure of midazolam, alfentanil, cyclosporine, dihydroergotamine, ergotamine, everolimus, fentanyl, pimozide, quinidine, sirolimus & tacrolimus.
Malaysia
