Manufacturer
PFIZER IRELAND PHARMACEUTICALS
Contents
Venlafaxine HCl
Indication
Depression including depression w/ associated anxiety. Generalized anxiety disorder (GAD) including long-term treatment. Social anxiety disorder (SAD or social phobia), panic disorder including prevention of relapse. Prevention of relapse & recurrence of depression.
Instruction
Should be taken with food: Take at the same time each day. Swallow whole, do not chew/crush/divide/dissolve. Cap may be carefully opened & entire contents sprinkled on a spoonful of applesauce. Swallow drug/food mixt w/o chewing immediately after prep & followed w/ glass of water.
Drug interaction
Severe AR w/ MAOIs. Serotonin syndrome w/ other serotonergic agents eg, triptans, SSRIs, other SNRIs, amphetamines, lithium, sibutramine, fentanyl & its analogues, tramadol, dextromethorphan, tapentadol, meperidine, methadone, pentazocine, St. John's wort; drugs impairing serotonin metabolism eg, linezolid & methylene blue or serotonin precursors eg, tryptophan supplements. Risk of QTc prolongation &/or ventricular arrhythmias w/ some antipsychotics & antibiotics. Decreased AUC & Cmax of indinavir. Increased AUC & Cmax of haloperidol, desipramine. Increased plasma conc w/ ketoconazole, metoprolol. Increased AUC of risperidone. Reduced metabolism w/ CYP2D6 inhibitors. Increased levels w/ CYP3A4 inhibitors. False +ve urine immunoassay screening tests for PCP & amphetamine. CNS-active drugs.
Malaysia
