Manufacturer
DUOPHARMA MANUFACTURING (BANGI) SDN BHD
Contents
Miconazole nitrate 2%
Indication
Skin fungal infections,Nail fungal infections,Vulvovaginal candidiasis
Instruction
Skin fungal infections
Adult: As 2% cream or powder: Apply over affected area bid for 2-6 weeks. As 2% powder along with 2% cream: Apply both formulations over affected area once daily for 2-6 weeks. Continue treatment for at least 1 week even after symptoms have resolved. Tinea pedis: As spray powder: Apply over affected area bid until lesions disappear.
Child: Same as adult dose.
Nail fungal infections
Adult: As 2% cream: Apply over affected area 1-2 times daily. Continue treatment for 10 days even after all lesions have disappeared.
Child: Same as adult dose.
Vulvovaginal candidiasis
Adult: As 2% cream (approx 5 g): Apply intravaginally at bedtime once daily for 10-14 days or bid for 7 days. Continue treatment even after pruritus and leukorrhoea have disappeared or menstruation begins
Drug interaction
May increase anticoagulant effect of warfarin. May increase serum concentrations or enhance the effects of phenytoin, fosphenytoin, sulfonylureas, saquinavir, vinca alkaloids, busulfan, docetaxel, Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressants (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate.Potentially Fatal: Increases the risk of cardiac arrhythmia with drugs known to prolong QT interval or induce torsade de pointes such as astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, and terfenadine. May increase risk of ergotism with necrosis of extremities with ergot alkaloids (e.g. ergotamine, dihydroergotamine). May inhibit metabolism of triazolam, oral midazolam and HMG-CoA reductase inhibitors (e.g. simvastatin, lovastatin).
Malaysia
