Exforge HCT 10/160/12.5mg Film-coated Tablet

Exforge HCT 10/160/12.5mg Film-coated Tablet

Danh mục: Drug Info Có sẵn
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Mô tả

Manufacturer
Novartis Farmaceutica S.A.
 
Contents
Per 10/160/12.5 mg Amlodipine 10 mg, valsartan 160 mg, hydrochlorothiazide 12.5 mg.
 
Indication
Essential HTN.
 
Instruction
May be taken with or without food.
 
Drug interaction
Increased incidence of hypotension, hyperkalemia & changes in renal function w/ ACE inhibitors, aliskiren. Increased K levels w/ K-sparing diuretics, K supplements, K-containing salt substitutes or drugs increasing K levels eg, heparin. Monitor serum K levels w/ skeletal muscle relaxants eg, curare derivatives. Monitor serum electrolyte balance w/ antidepressants, antipsychotics, antiepileptics. Drugs causing hypokalemia eg, corticosteroids, ACTH, amphotericin, penicillin G, carbenoxolone, antiarrhythmics. Decreased hypertensive effects w/ NSAIDs including COX-2 inhibitors. Increased amlodipine plasma conc w/ ketoconazole, itraconazole, ritonavir. Increased systemic exposure to valsartan w/ rifampin, ciclosporin, ritonavir. Electrolyte imbalance w/ digitalis glycosides. Combination w/ antihypertensives; insulin, oral antidiabetic agents; anionic exchange resins, allopurinol, amantadine, diazoxide, cytotoxic drugs, anticholinergic agents, vit D, Ca salts, methyldopa, noradrenaline, barbiturates, narcotics, alcohol.

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