Manufacturer
NOVARTIS PHARMA STEIN AG
Contents
Nitroglycerin
Indication
Stable angina, Prophylaxis of phlebitis and extravasation secondary to venous cannulation.
Instruction
Stable angina: Adult: As patch releasing 2.5-20 mg/24 hr: Apply 1 patch onto a fresh area of skin (chest, upper arms, thigh or shoulder). Max: 20 mg daily.
Prophylaxis of phlebitis and extravasation secondary to venous cannulation
Adult: As patch releasing 2.5-20 mg/24 hr: Apply 5 mg patch distal to the IV site, replace patch at a different skin site either daily or after 3-4 days depending on the patch; continue for as long as the IV infusion is maintained.
Drug interaction
Enhanced hypotensive effect w/ vasodilators and other hypotensive drugs. Reduced efficacy (oral/buccal preparations) w/ drugs that cause dry mouth (e.g. TCAs, other antimuscarinics). Increased vasodilatory effect w/ acetylcysteine. May reduce the thrombolytic activity of alteplase. May increase the bioavailability of dihydroergotamine which may lead to coronary vasoconstriction.Potentially Fatal: Potentiation of hypotensive effect w/ PDE5 inhibitors (e.g. sildenafil, tadalafil, vardenafil), riociguat and other organic nitrates w/ nitric oxide (NO) donors. May reduce the anticoagulant effect of heparin.
Malaysia
