Manufacturer
NOVARTIS PHARMA STEIN AG
Contents
Per 10/320 mg tab Amlodipine besylate 10 mg, valsartan 320 mg
Indication
Essential HTN in patients whose BP is inadequately controlled by monotherapy.
Instruction
May be taken with or without food.
Drug interaction
Amlodipine: Increased exposure of simvastatin. Increased plasma conc w/ CYP3A4 inhibitors. Valsartan: Concomitant use w/ K supplements, K-sparing diuretics, salt substitutes containing K or other drugs that increase K levels. Concomitant use of angiotensin II antagonist w/ NSAIDs may attenuate antihypertensive effects. Furthermore, increase worsening of renal function in vol-depleted or w/ compromised renal function elderly patients. Co-administration of inhibitors of uptake transporter (rifampin, ciclosporin) or efflux transporter (ritonavir) may increase systemic exposure to valsartan.
Malaysia
