Manufacturer
Novartis
Contents
Aliskiren
Indication
Treatment of essential hypertension in adults.
Instruction
Oral use. The tablets should be swallowed whole with some water. Rasilez should be taken once a day, with or without food, preferably at the same time each day. Patients should establish a convenient daily schedule of drug intake and maintain a steady temporal relationship with food intake. Concomitant intake with fruit juice and/or drinks containing plant extracts (including herbal teas) should be avoided.
Drug interaction
Caution should be exercised when Rasilez is administered with ketoconazole, verapamil or other moderate P-gp inhibitors (clarithromycin, telithromycin, erythromycin, amiodarone). As with other agents acting on the renin-angiotensin system, NSAIDs may reduce the antihypertensive effect of aliskiren. In some patients with compromised renal function (dehydrated patients or elderly patients) aliskiren given concomitantly with NSAIDs may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
Malaysia
