Manufacturer
Sandoz Private Limited
Contents
Tacrolimus
Indication
Prophylaxis of rejection in kidney graft transplant, Treatment for rejection of pancreas transplant, Treatment of lung transplant rejection, Treatment of liver transplant rejection, Treatment of cardiac transplant rejection, Prophylaxis of rejection in liver graft transplant, Treatment of kidney transplant rejection, Prophylaxis of cardiac graft rejection,Treatment for rejection of intestine transplant.
Instruction
Should be taken on an empty stomach. Take at least 1 hr before or 2-3 hr after meals. Avoid grapefruit & grapefruit juice.
Drug interaction
Increased blood levels w/ HCV protease inhibitors (e.g. boceprevir, telaprevir), HIV protease inhibitors (e.g. saquinavir, ritonavir, nelfinavir), macrolide antibiotics (e.g. erythromycin), antifungal agents (e.g. fluconazole, ketoconazole, itraconazole, voriconazole), ciclosporin, lansoprazole, amiodarone, cimetidine, Mg-Al-hydroxide, metoclopramide. Decreased blood levels w/ rifampicin, phenytoin, metamizole, carbamazepine, isoniazid. May increase nephrotoxic or neurotoxic effects of NSAIDs, aminoglycosides, vancomycin, gyrase inhibitors, sulfamethoxazole+trimethoprim, ganciclovir, aciclovir. May reduce effect of live attenuated vaccines. Increased hyperkalaemic effect w/ K-sparing diuretics (e.g. spironolactone, amiloride, triamterene).
Malaysia
