Manufacturer
DUOPHARMA (M) SDN. BHD.
Contents
Fentanyl
Indication
Premedication before anaesthesia, Adjunct to general anaesthesia.
Instruction
Premedication before anaesthesia
Adult: 50-100 mcg to be given 30-60 min prior to induction of anaesth.
Elderly: Dose reduction may be needed.
Adjunct to general anaesthesia
Adult: Patients w/ spontaneous respiration: Initially, 50-200 mcg followed by supplements of 50 mcg. Max: 200 mcg. Admin infusion rates of 0.05-0.08 mcg/kg/min. Patients w/ assisted ventilation: Initially, 300-3,500 mcg (up to 50 mcg/kg) followed by supplements of 100-200 mcg depending on patient's response. Loading dose (alternatively via bolus): Approx 1 mcg/kg/min given for the 1st 10 min followed by infusion of approx 0.1 mcg/kg/min.
Child: 2-12 yr Initially, 2-3 mcg/kg followed by supplements of 1 mcg/kg.
Elderly: Dose reduction may be needed.
Drug interaction
Concomitant use w/ CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, troleandomycin, azole antifungals, ritonavir, amiodarone, nefazodone, aprepitant, diltiazem and verapamil) increases serum levels of fentanyl and may potentiate fatal resp depression. Increased risk of life-threatening serotonins syndrome w/ SSRIs, SNRIs and MAOIs. May reduce serum levels w/ rifamycin derivatives. Enhanced depressant effect w/ general anaesth, tranquilisers, barbiturates and narcotics. May increase excretion w/ ammonium Cl. May increase hypotensive effect w/ phenothiazines. May reduce efficacy of pegvisomant.
Malaysia
