Manufacturer
DUOPHARMA (M) SDN. BHD.
Contents
Metoprolol tartrate
Indication
Angina pectoris,Hypertension,Adjunct in hyperthyroidism,Prophylaxis of migraine,Heart failure,Cardiac arrhythmias.
Instruction
Maybe taken with or without food.
Drug interaction
May enhance cardiodepressant effect with anaesthetic drugs (e.g. cyclopropane). May enhance hypoglycaemic effects of insulin. Increased serum concentration with CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine, propafenone). May increase atrioventricular conduction and decrease heart rate with digitalis glycosides, clonidine, diltiazem, verapamil. Additive effects with catecholamine-depleting drugs (e.g. reserpine) and MAO inhibitors. Increased blood pressure lowering effect with TCA, barbiturates, phenothiazines, and other antihypertensive agents. Reduced antihypertensive effects with NSAIDs (e.g. indometacin). May enhance vasoconstrictive action of ergot alkaloids.
Malaysia
