Manufacturer
GRACURE PHARMACEUTICALS LTD.
Contents
Celecoxib 200mg
Indication
Osteoarthritis, Acute pain, Primary dysmenorrhoea, Ankylosing spondylitis, Rheumatoid arthritis, Juvenile idiopathic arthritis.
Instruction
May be taken with or without food.
Drug interaction
Increased risk of gastrointestinal ulceration or bleeding with anticoagulants (e.g. warfarin, apixaban), antiplatelet agents (e.g. aspirin), SSRIs, corticosteroids (e.g. glucocorticoids), other NSAIDs. May reduce the antihypertensive effect of ACE inhibitors, angiotensin II receptor antagonists, diuretics, β-blockers and other antihypertensive agents. May increase the nephrotoxic effect of ciclosporin and tacrolimus. Increases the serum concentration of lithium, digoxin and methotrexate. Increased plasma concentration with CYP2C9 inhibitors (e.g. fluconazole). Decreased plasma concentrations with CYP2C9 inducers (e.g. rifampicin, carbamazepine, barbiturates). May increase serum concentration and toxicity of CYP2D6 substrates (e.g. aripiprazole, perhexiline, atomoxetine).
Malaysia
